熊碧权

职称：教授

性别：男

职务：

办公电话：

移动电话：

家庭电话：

家庭住址：

电子邮箱：xiongbiquan@126.com

工作学习经历

主讲课程

《化学反应工程》《化学工艺学》《环境化学》

研究方向

1、有机磷化学：聚焦含磷化合物的高效构建与转化，探索P-H、P(O)-OH等磷氢键及P(III)亲核试剂的新型活化模式，为有机磷功能分子提供绿色合成新路径。

2、工业催化：致力于非均相催化剂及高效均相催化体系的设计，解决催化反应中活性、选择性与可回收性问题，推动绿色催化工艺发展。

3、精细有机化工： 面向高价值精细化学品（如药物中间体、功能助剂）开展合成工艺开发，如特种环氧树脂。

主要学术成果

围绕绿色有机合成主题，聚焦于催化新技术的开发，开展磷资源的高值化转化和对亚甲基醌类化合物的官能团化反应研究。在Green Chemistry、Chinese Journal of Chemistry、Organic Letters、Organic Chemistry Frontiers等期刊发表学术论文60余篇。

承担项目：

1. 国家自然科学青年科学基金项目，21606080，过渡金属催化惰性P-O/P(O)-OH键构建P-C/P-Z键及其机理研究，主持，已结题；

2. 湖南省教育厅优秀青年项目，16B111，过渡金属催化有机磷酸/膦酸选择性官能团化研究，主持，已结题；

3. 湖南省自然科学基金青年项目，2019JJ50203，有机膦酸酯P-H/P-OH键选择性构建P-C/P-Z键及其催化应用研究，主持，已结题；

4. 湖南省教育厅重点项目，19A197，过渡金属负载型糖基催化剂的制备及其催化P-H键选择性官能团化反应研究，主持，已结题；

5. 湖南省自然科学基金面上项目，2023JJ30274，功能化壳聚糖负载铱基多孔材料的制备与催化P-H/P-OH 键转化研究，主持，已结题；

6. 湖南省教育厅重点项目，23A0497，过渡金属催化对亚甲基苯醌的区域选择性官能团化反应研究，主持，已结题；

7. 湖南省自然科学基金面上项目，2026JJ50131，无机亚/次磷酸盐磷氢键的可控活化及有机转

化研究，主持，在研

代表性论文：

1. Zhu, Longzhi; * Xie, Shuangjiao; Yang, Hongbo; Hong, Yingle; Chen, Lin; Luo, Weiwei; Jin, Sha; Liu, Lixin; * Xiong, Biquan.* Catalyst-free synthesis of phosphinochalcogenoic anhydrides via the oxygen–chalcogen exchange with elemental sulfur or selenium. Green Chemistry 2026, 28(13), 5848–5856.

2. Xu, Weifeng; Xiong, Biquan;* Zhu, Longzhi;* Xu, Shipan; Meng, Zhengong; Wong, Wai-Yeung.* Ruthenium-Catalyzed Heck-Type Regioselective Benzylation of Terminal Alkynes via the Cleavage of Carbon‑Carbon Triple Bond. Chinese Journal of Chemistry 2026, 44(9), 1406–1418.

3. Xiong, Biquan;* Li, Meng; Cao, Renfeng; Yue, Sitong; Xu, Weifeng; Liu, Yu; Zhu, Longzhi;* Tang, Ke-Wen. Elemental Sulfur/Selenium-Mediated Metal-Free Phosphinothioation and Phosphinoselenoation of Vinylsulfonium Salts with P-H Bonds. The Journal of Organic Chemistry 2025, 90(1), 275–291.

4. Zheng, Siya; Xu, Weifeng; Zhu, Longzhi;* Lei, Jian;* Xiong, Biquan.* Copper-Catalyzed Vinylsulfonium Salt Diversification with P(O)-OH Bonds: Phosphoryloxylation via an Ionic Ring-Opening Process. The Journal of Organic Chemistry 2025, 90(38), 13525–13542.

5. Xiong, Biquan;* Zheng, Siya; Xu, Weifeng; Liu, Yu; Zhu, Longzhi;* Tang, Ke-Wen; Sun, Zelin;* Wong, Wai-Yeung.* Copper-catalyzed phosphorothiolation/seleno(telluro)phosphorylation of vinylsulfonium salts with P(III)-nucleophiles via the insertion of elemental sulfur/selenium/tellurium. Organic Chemistry Frontiers 2025, 12(3), 936–946.

6. Minjing Yuan,‡ Zikang Li,‡ Weifeng Xu, Biquan Xiong,* Yu Liu, Min Liu,* Ke-Wen Tang, and Longzhi Zhu*, Copper-catalyzed Regioselective Cyanation/Diarylmethylation of Formamides: Construction of α-Cyano Functionalized tet-ra-Substituted Olefins, Chinese Journal of Chemistry 2025, 43(2), 191–198.

7. Xu, Weifeng; Fan, Liyong; Li, Zikang; Zhu, Longzhi;* Liu, Min;* Xiong, Biquan.* Copper-Catalyzed Stereoselective Cyanation/Phosphorylation of Formamides with TMSCN and P(O)-H Bonds. Organic Letters 2025, 27(20), 5264–5269.

8. Yuan, Minjing;‡ Zhu, Longzhi;‡ Xu, Weifeng; Zeng, Yilong; Lu, Guo-Liang;* Xiong, Biquan;* Qiu, Renhua.* Copper-Catalyzed Cascade Phosphorodithiolation/Cyclization of β‑Ketodinitriles: Organic Transformation of P₄S₁₀. Chinese Journal of Chemistry 2025, 43(17), 2159–2166.

9. Zhu, Longzhi;* Guo, Furong; Luo, Weiwei; Xie, Shuangjiao; Zhu, Tingyuan; Liao, Zihe; Xiong, Biquan;* Liu, Yu; Tang, Ke-Wen; Qiu, Renhua.* Metal-free triphenyl phosphite-catalyzed Ritter-type amidation of allylic alcohols. Green Chemistry 2025, 27(36), 11125–11132.

10. Li, Meng; Zhu, Longzhi;* Xu, Weifeng; Jin, Sha;* Xiong, Biquan.* Copper-Catalyzed Divergent C-S Bond Cleavage of Vinylsulfonium Salts: Controllable Phosphoryloxylation and Phosphinoylation. Organic Letters 2025, 27(47), 13091–13097.

11. Xu, Shipan; Xiong, Biquan;* Yuan, Minjing; Xu, Weifeng; Cao, Renfeng; Cao, Fan;* Zhu, Longzhi;* Yin, Shuang-Feng.* Synthesis of Layered Copper-Based 2D-MOFs for Enhanced Catalytic Regioselective Phosphorylation of Alkynes and P–H Bonds. Advanced Synthesis & Catalysis 2025, 367(8), e202401414.

12. Xu, Weifeng; Yuan, Minjing;* Zhu, Longzhi; Jin, Sha; Xiong, Biquan.* Transition-Metal-Free, Visible-Light-Driven Regioselective Phosphinoylation/Hydrazonation of Unactivated Alkenes with Arylhydrazines and H-Phosphine Oxides. Chinese Journal of Chemistry 2025, 43(21), 2787–2794.

13. Longzhi Zhu,* Weiwei Luo, Furong Guo, Lin Chen, Ying Tang, Biquan Xiong,* Yu Liu, Ke-Wen Tang and Renhua Qiu,* Halide-free and metal-free allylic thiolation/selenation of P(O)H compounds with sulfur/selenium and allylic alcohols, Green Chemistry 2024, 26(21), 10886–10892.

14. Minjing Yuan, Zikang Li, Wenli Shang, Biquan Xiong,* Weifeng Xu, Longzhi Zhu,* Yu Liu, Ke-Wen Tang, and Wai-Yeung Wong*, Iron-Catalyzed Cross-Dehydrogenative Coupling of para-Quinone Methides with Formamides: in-situ Activation of C(sp2)-H Bonds, Journal of Organic Chemistry 2024, 89(22), 16663–16678.

15. Fan Cao,* Jinli Wu, Guilin Dai, Jing Gao, Quan Zhou, Panliang Zhang, Biquan Xiong,* Kewen Tang*, Electrospun porous polyacrylonitrile nanofibrous membrane grafted with branched polyethyleneimine for efficient adsorption of Cu2+ and Pb2+ from polluted water, Journal of Environmental Chemical Engineering, 2024, 12(6), 114424.

16. Le, Liyuan; Yin, Mingming; Zeng, Huifan; Xie, Wuxing; Zhou, Wenjun; Chen, Yi;* Xiong, Biquan;* Yin, Shuang-Feng; Kambe, Nobuaki; Qiu, Renhua,* Nickel-Catalyzed C(sp3)–Sb Coupling of Chlorostibines with Unactivated Alkyl Chlorides and In Vitro Anticancer Activity of Products. Organic Letters 2023, 26 (1), 344-349.

17. Xiong, Biquan; Xu, Shipan; Xu, Weifeng; Liu, Yu; Zhang, Limin; Tang, Ke-Wen;* Yin, Shuang-Feng;* Wong, Wai-Yeung,* Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols. Organic Chemistry Frontiers 2022, 9 (14), 3807-3817.

18. Xiong, Biquan; Feng, Xiaofeng; Zhu, Longzhi; Chen, Tieqiao; Zhou, Yongbo; Au, Chak-Tong; Yin, Shuang-Feng,* Direct Aerobic Oxidative Esterification and Arylation of P(O)–OH Compounds with Alcohols and Diaryliodonium Triflates. ACS Catalysis 2015, 5 (2), 537-543.

19. Xiong, Biquan;* Yuan, Minjing; Shi, Chonghao; Zhu, Longzhi;* Cao, Fan;* Xu, Weifeng; Ren, Yining; Liu, Yu; Tang, Ke-Wen, Recent Advances in the Application of P(III)-Nucleophiles to Create New P−C Bonds through Michaelis–Arbuzov-Type Rearrangement. Topics in Current Chemistry 2024, 382, 10.

20. Xiong, Biquan;* Shi, Chonghao; Ren, Yining; Xu, Weifeng; Liu, Yu; Zhu, Longzhi;* Cao, Fan;* Tang, Ke-Wen; Yin, Shuang-Feng, Zn-Catalyzed Dehydroxylative Phosphorylation of Allylic Alcohols with P(III)-Nucleophiles. The Journal of Organic Chemistry 2024, 89 (5), 3033-3048.

21. Ren, Yining; Chen, Liyong; Xie, Mingyu; Xu, Shipan; Liu, Yu; Zhu, Longzhi;* Xu, Weifeng;* Xiong, Biquan,* Regioselective hydrophosphorylation of alkynes by a functionalized heterogeneous Cu-chitosan based catalyst. Applied Catalysis A, General 2024, 684, 119900.

22. Fan, Liyong; Zhu, Longzhi; Shang, Wenli; Yin, Mingming; Xiong, Biquan;* Xie, Wuxing; Cao, Fan; Liu, Yu; Chen, Yi;* Qiu, Renhua,* Cascade Cyclization/Amination of para‐Quinone Methides with β‐Ketodinitriles: Synthesis of Polysubstituted Furans. Advanced Synthesis & Catalysis 2024, 366, 2101-2108.

23. Xiong, Biquan;* Si, Lulu; Zhu, Longzhi;* Liu, Yu; Xu, Weifeng; Tang, Ke-Wen; Yin, Shuang-Feng; Qian, Peng-Cheng; Wong, Wai-Yeung,* Copper-Catalyzed Aerobic Oxidative/Decarboxylative Phosphorylation of Aryl Acrylic Acids with P(III)-Nucleophiles. The Journal of Organic Chemistry 2023, 88 (17), 12502-12518.

24. Shang, Wenli; Zhu, Longzhi; Li, Zikang; Xu, Weifeng; Xiong, Biquan;* Liu, Yu; Tang, Ke-Wen; Qian, Peng-Cheng; Yin, Shuang-Feng;* Wong, Wai-Yeung,* Ruthenium-Catalyzed 1,6-Hydroalkylation of para-Quinone Methides with Ketones via the in Situ Activation of C(sp3)–H Bonds. The Journal of Organic Chemistry 2023, 88 (23), 16196-16215.

25. Xiong, Biquan;* Shi, Chonghao; Xu, Weifeng; Liu, Yu; Zhu, Longzhi; Tang, Ke-Wen;* Yin, Shuang-Feng; Wong, Wai-Yeung,* Visible-Light-Induced Cascade Phosphinoylation/Cyclization of Phenacylmalononitriles with Secondary H-phosphine Oxides. Advanced Synthesis & Catalysis 2022, 364 (24), 4392-4401.

26. Xu, Shipan; Xie, Jun; Liu, Yu; Xu, Weifeng; Tang, Ke-Wen; Xiong, Biquan;* Wong, Wai-Yeung,* Silver-Catalyzed Regioselective Phosphorylation of para-Quinone Methides with P(III)-Nucleophiles. The Journal of Organic Chemistry 2021, 86 (21), 14983-15003.

27. Xiong, Biquan;* Xu, Shipan.; Liu, Yu; Tang, Kewen;* Wong, Wai-Yeung,* Metal-Free, Acid/Phosphine-Induced Regioselective Thiolation of p-Quinone Methides with Sodium Aryl/Alkyl Sulfinates. The Journal of Organic Chemistry 2021, 86 (2), 1516-1527.

28. Xiong, Biquan;* Xu, Shipan; Liu, Yu; Tang, Ke-Wen;* Qian, Peng-Cheng;* Wong, Wai-Yeung,* Recent Progress in the Selective Functionalization of P(O)–OH Bonds. Topics in Current Chemistry 2021, 379 (1), 5.

29. Xiong, Biquan;* Xu, Shipan; Zhu, Yu; Yao, Lei; Zhou, Congshan; Liu, Yu; Tang, Ke‐Wen;* Wong, Wai‐Yeung,* Metal‐Free, N‐Iodosuccinimide‐Induced Regioselective Iodophosphoryloxylation of Alkenes with P(O)−OH Bonds. Chemistry – A European Journal 2020, 26 (43), 9556-9560.

30. Xiong, Biquan;* Wang, Gang; Zhou, Congshan; Liu, Yu; Zhang, Panliang; Tang, Kewen,* Bu4NI-Catalyzed Dehydrogenative Coupling of Diaryl Phosphinic Acids with C(sp3)–H Bonds of Arenes. The Journal of Organic Chemistry 2018, 83 (2), 993-999.

31. Xiong, Biquan; Li, Mei; Liu, Yanxi; Zhou, Yongbo; Zhao, Changqiu; Goto, Midori; Yin, Shuang‐Feng;* Han, Li‐Biao,* Stereoselective Synthesis of Phosphoryl‐Substituted Phenols. Advanced Synthesis & Catalysis 2014, 356 (4), 781-794.

32. Xiong, Biquan; Shen, Ruwei; Goto, Midori; Yin, Shuang‐Feng;* Han, Li‐Biao,* Highly Selective 1,4‐ and 1,6‐Addition of P(O)−H Compounds to p‐Quinones: A Divergent Method for the Synthesis of C‐ and O‐Phosphoryl Hydroquinone Derivatives. Chemistry – A European Journal 2012, 18 (52), 16902-16910.

33. Zhu, Longzhi; Ren, Yining; Liu, Xianping; Xu, Shipan; Li, Tao;* Xu, Weifeng; Li, Zikang;* Liu, Yu; Xiong, Biquan,* Catalyst- and Additive‐free, Regioselective 1,6-Hydroarylation of para-Quinone Methides with Anilines in HFIP. Chemistry-an Asian Journal 2023, 18, e202300792.

34. Xiong, Biquan;* Si, Lulu; Zhu, Longzhi; Wu, Rong; Liu, Yu; Xu, Weifeng; Zhang, Fan; Tang, Kewen;* Wong, Wai-Yeung,* Room-Temperature ZnBr2 -Catalyzed Regioselective 1,6-Hydroarylation of Electron-Rich Arenes to para-Quinone Methides: Synthesis of Unsymmetrical Triarylmethanes. Chemistry-an Asian Journal 2023, 18 (3), e202201156.

35. Xiong, Biquan;* Si, Lulu; Liu, Yu; Xu, Weifeng; Jiang, Tao; Cao, Fan;* Tang, Ke‐Wen; Wong, Wai‐Yeung,* Metal‐free, Phosphoric Acid‐catalyzed Regioselective 1,6‐Hydroarylation of para‐Quinone Methides with Indoles in Water. Chemistry – An Asian Journal 2022, 17 (9).

36. Xiong, Biquan;* Shang, Wenli; Xu, Weifeng; Liu, Yu; Tang, Ke‐Wen; Wong, Wai‐Yeung,* Acid‐Catalyzed Regioselective Synthesis of α‐Diarylmethyl Substituted Phenols and para‐Quinone Methides in Water. Asian Journal Of Organic Chemistry 2022, 11 (8), e202200295.

37. Xie, Jun;* Chen, Min; Peng, Lin-Ling; Wu, Jia-Qi; Zhou, Quan; Zhou, Cong-Shan; Xiong, Bi-Quan;* Liu, Yu,* Facile preparation of Cu(II)-modified nitrogen-rich covalent organic polymer for cross-dehydrogenative ortho-aminomethylation of phenols. Catalysis Communications 2021, 159.

38. Xiong, Biquan;* Wang, Gang; Zhou, Congshan; Liu, Yu; Yang, Chang-An; Zhang, Panliang; Tang, Kewen; Zhou, Quan,* Organocatalytic, regioselective allylic- and 1,6-substitution of quinone monoketals with diaryl H-phosphine oxides. Journal of Organometallic Chemistry 2019, 885, 21-31.

39. Xiong, Biquan;* Wang, Gang; Zhou, Congshan; Liu, Yu; Xu, Weifeng; Xu, Wen‐Yuan; Yang, Chang‐An; Tang, Ke‐Wen,* Base‐Catalyzed Stereoselective 1,6‐Conjugated Addition/Aromatization of P(O)–H Compounds with para‐Quinone Methides. European Journal of Organic Chemistry 2019, 2019 (20), 3273-3282.

40. Wang, Gang; Xiong, Biquan;* Zhou, Congshan; Liu, Yu; Xu, Weifeng; Yang, Chang‐An; Tang, Ke‐Wen; Wong, Wai‐Yeung,* Copper‐Catalyzed Diphenylation of P(O)‐OH Bonds with Cyclic Diaryliodonium Salts. Chemistry – An Asian Journal 2019, 14 (23), 4365-4374.

获授权中国发明专利：

[1] 熊碧权, 唐课文, 张盼良, 刘宇, 许卫凤. 一种以亚胺催化P(O)-OH类化合物与醇高效酯化的合成方法. 中国发明专利, 专利号：ZL 201710127845.0

[2] 熊碧权, 王刚, 许卫凤, 唐课文. 一种手性诱导高效制备含R-/S-二芳基甲基取代手性有机膦酸酯的新方法. 中国发明专利, 专利号: ZL 201811431075.X

[3] 熊碧权, 王刚, 许卫凤, 唐课文. 一种以P(O)-H化合物高效制备含二芳基甲基取代有机膦酸酯的新方法. 中国发明专利, 专利号: ZL 201811431081.5

[4] 熊碧权, 唐课文, 张盼良, 刘宇, 李昊天, 许卫凤. 一种以含P(O)-OH类化合物与酚高效酯化制备有机磷酸酯类化合物的方法. 中国发明专利, 专利号: ZL 201710128014.5

[5] 熊碧权, 唐课文, 张盼良, 刘宇, 许卫凤. 一种以含P(O)-OH类化合物与醇高效酯化制备有机磷酸酯类化合物的方法. 中国发明专利, 专利号: ZL 201611136064.X

[6] 熊碧权, 王刚, 唐课文, 张盼良, 许卫凤, 刘宇. 一种以芳基重氮四氟硼酸盐与腈制备有机酰胺类化合物的方法. 中国发明专利, 专利号: ZL 201810053415.3

[7] 熊碧权, 王刚, 唐课文, 张盼良, 刘宇, 许卫凤. 一种高立体选择性制备反式芳香叔胺偶氮类化合物的方法. 中国发明专利, 专利号: ZL 201711372354.9

[8] 熊碧权, 王刚, 唐课文, 张盼良, 刘宇, 许卫风. 一种以P(O)-OH化合物与含甲基取代芳香烃制备有机磷酸酯类化合物的方法. 中国发明专利, 专利号: ZL 201710766975.9

[9] 熊碧权, 王刚, 唐课文, 许卫凤. 一种制备邻二芳基磷酰基取代酚类衍生物的新方法. 中国发明专利, 专利号: ZL 201810898221.3

[10] 熊碧权, 王刚, 唐课文, 刘宇, 许卫凤. 一种制备2’-碘代[1,1’-联芳基]-2-有机膦酸酯化合物的新方法. 中国发明专利, 专利号: ZL 201910372819.3

[11] 熊碧权, 王刚, 祝雨, 刘宇, 许卫凤, 唐课文. 一种烯烃高效双官能团化制备2-碘-1-磷酰基取代烷烃化合物的方法. 中国发明专利, 专利号: ZL 201910897273.3

[12] 熊碧权, 许世攀. 一种制备二芳基甲基取代膦酸酯的新方法. 中国发明专利, 专利号: ZL 202010890855.1

[13] 熊碧权, 许世攀. 一种铜催化二芳基磷氧与醇氧化脱氢偶联制备膦酸酯的新方法. 中国发明专利, 专利号: ZL 202010888097.X

[14] 熊碧权, 许世攀. 一种铜催化二芳基磷氧与硫醇氧化脱氢偶联制备硫代膦酸酯的新方法. 中国发明专利, 专利号: ZL 202010890846.2

[15] 熊碧权, 许世攀, 唐课文. 一种制备二芳基甲基取代硫醚的方法. 中国发明专利, 专利号: ZL 202010890883.3

[16] 熊碧权, 许世攀, 唐课文. 一种制备磷酰基偶氮类化合物的新方法. 中国发明专利, 专利号: ZL 202010890857.0

[17] 熊碧权, 司路路, 许卫凤, 唐课文. 一种制备2-二芳基甲基取代吲哚类化合物的绿色新方法. 中国发明专利, 专利号: ZL 202110129718.0

[18] 熊碧权, 司路路, 许卫凤, 唐课文. 一种制备3-二芳基甲基取代吲哚类化合物的绿色新方法. 中国发明专利, 专利号: ZL 202110129739.2

[19] 熊碧权, 尚文丽, 许卫凤, 唐课文. 一种制备1-二芳基甲基取代-2-萘酚类化合物的绿色新方法. 中国发明专利, 专利号: ZL 2021 1 0129716.1

[20] 熊碧权, 许世攀, 唐课文, 江韬, 许卫凤. 一种银催化制备4-二甲基芳基取代苯酚类化合物的新方法. 中国发明专利, 专利号: ZL 2022 1 0072158.4

[21] 熊碧权, 司路路, 朱龙志, 许卫凤, 刘宇, 唐课文, 张盼良, 一种制备4-二芳基甲基取代酚类化合物的方法. 中国发明专利, 专利号: ZL 202211113555.8

[22] 熊碧权, 尚文丽, 许卫凤, 唐课文, 朱龙志, 曹帆, 刘宇, 一种制备 α-二芳基甲基取代酮类化合物的方法. 中国发明专利, 专利号: ZL 202310019132.8

[23] 熊碧权, 尚文丽, 许卫凤, 唐课文, 一种制备2-二芳基甲基取代-1-萘酚类化合物的绿色新方法, 中国发明专利, 专利号: ZL 202210072586.7

个人简介

熊碧权：教授、硕士生导师；博士研究生，毕业于湖南大学。主要从事有机磷化学、工业催化与高值精细化工产品开发方面的研究。先后获得国家自然科学基金青年项目1项，湖南省教育厅研究项目3项，湖南省自然科学基金研究项目3项等资助，2021年获评“湖南省第二届优秀研究生导师”，以第一作者和通讯作者在ACS Catal., Green Chem., Org. Chem. Front., Org. Lett., Top. Curr. Chem., Adv. Catal. Synth., J. Org. Chem等期刊发表SCI论文60余篇，以第一发明人获授权中国发明专利20余项。