承担项目: 1. 近红外发射双光子荧光纳米探针的设计、合成及其肿瘤分子成像分析,国家自然科学基金面上项目(21675042 ),主持,2017-2020。 2. 可逆激活型近红外纳米荧光探针的构建及其生物成像研究,湖南省自然科学基金面上项目(2018JJ2017),主持,2018-2020。 代表性论文: (1) Huan Peng, Suna Kong, Xia Deng, Qirong Deng, Fengpei Qi, Changhui Liu*, Ruiren Tang*. Development of a ratiometric fluorescent probe with zero cross-talk for detection of SO2derivatives in foods and live cells. Journal of Agricultural and Food Chemistry, 2023, 71(39): 14322-14329. (2) Nan Wang, Jianke Su, Qirong Deng, Aijuan Liu, Fengpei Qi, Jin Zhang, Liping Long, Suna Kong, Changhui Liu*, Ruiren Tang*, G-quadruplex-lighted EVCP for the construction of ratiometric fluorescent sensors: detection of hydrogen peroxide and oxidase substrate, Dyes and Pigments, 2020, 177, 108132. (3) 刘长辉, 李银辉, 齐风佩, 龙立平, 杨荣华*. 近红外双发射荧光探针比率检测高/半胱氨, 中国科学-化学, 2017, 47, 1015-1021. (4) Changhui Liu, Weiju Chen, Zhihe Qing, Jing Zheng, Yue Xiao, Sheng Yang, Lili Wang, Yinhui Li, Ronghua Yang*. In vivo lighted fluorescence via Fenton reaction: approach for imaging of hydrogen peroxide in living systems, Analytical Chemistry, 2016, 88, 3998-4003. (5) Changhui Liu, Jing Zheng, Li Deng, Cheng Ma, Jishan Li, Yinhui Li, Sheng Yang, Jinfeng Yang, Jing Wang, Ronghua Yang*. Targeted intracellular controlled drug delivery and tumor therapy through in situ forming Ag Nanogates on mesoporous silica nanocontainers, ACS Applied Material & Interfaces, 2015, 7(22), 11930-11938. (6) YiBo Zhou, Zhengxuan Gu, Changhui Liu, Sheng Yang, Xiaofei Ma, Qiaoshu Chen, Yanli Lei, Ke Quan, Juewen Liu, Zhihe Qing*, Ronghua Yang*. A polymeric nanobeacon for monitoring the fluctuation of hydrogen polysulfides during fertilization and embryonic development. Angewandte Chemie International Edition, 2022, 61(16): e202114504. 代表性专利: (1) 刘长辉, 王家佳, 王波, 吴世新, 朱奥林, 谌秀婷. 一种检测粘度的比色和比率荧光探针及其制备方法, CN 2023118333713 (2) 刘长辉,李月,银一笑,董艳,赵芝慧,齐风佩,彭欢.一种快速检测碘离子的近红外荧光分析方法,国家发明专利, ZL 2022 1 0327315.1. (3) 刘长辉,王贞睿,齐风佩,曹一鸣,罗苗,肖刘平.一种黑茶抗氧化活性的荧光分析方法,国家发明专利, ZL 2018 1 0692139.5. |